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Coronavirus (COVID-19) cases are still rising, with 116,001 cases across the world as of Tuesday, March 10. COVID-19 has already killed 4,089 - the majority of lived in the epidemic’s epicentre China. With global cases of COVID-19 surpassing 100,000, scientists are racing to research methods of prevent new viral infections. The second is fusion with a cell membrane, either on the surface of the cell or at an internal location. In the case of coronaviruses, the first step requires specific proteins in the viral envelope, called spike (S) proteins, undergo a biochemical modification. This step is called S protein priming. The enzymes responsible for S protein priming are potential therapeutic targets as inhibiting their mechanism may prevent a virus from being able to enter a cell. The authors wrote in Cell: “Unravelling which cellular factors are used by SARS-CoV-2 for entry might provide insights into viral transmission and reveal therapeutic targets.”The study’s senior author is Stefan Pöhlmann, a professor for Infection Biology at Georg-August-University. Professor Pöhlmann’s team revealed evidence the SARS-CoV-2 S protein binds to the same receptor as the SARS virus S protein. The receptor is called angiotensin-converting enzyme 2 or ACE2.A previous paper in th...
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