Reproductive aging in female mammals is an irreversible process. As more people, mainly in developed countries, are delaying pregnancies there has been an associated rise in the use of assisted reproductive technologies (ARTs) such as IVF. These technologies are expensive, risky and not guaranteed to be successful. Is there an alternative, safer way to prevent decline in reproductive aging. In this video I discuss a recent study that found that NMN, an NAD+ precursor, improved oocyte quality and reproduction in older mice. Paper; Bertoldo, M. J., Listijono, D. R., Ho, W.-H. J., Riepsamen, A. H., Goss, D. M., Richani, D., … Wu, L. E. (2020). NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell Reports, 30(6), 1670-1681.e7.
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