5 Things That Can Keep You From Getting an Unpleasant Cold Sore on Your Lips If you have a group of small blisters around your mouth or lips, you are most likely dealing with cold sores. The very first symptom is having a spot on your mouth that burns or itches until it develops into a blister. The spot may become red, swollen, or sore when the first symptoms go away. These blisters can break open, ooze, and turn into a scab after a few days.

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